Patients with HRR mutations are at risk
The presence of pathogenic HRR mutations, of which BRCA1 and BRCA2 are among the most common1, has been associated with an early onset of disease, aggressive tumour growth, higher recurrence, and poor prognosis3.
HRR: Homologous recombination repair
BRCA1: Breast cancer gene 1
BRCA2: Breast cancer gene 2
REFERENCES: 1. Teyssonneau D, Margot H, Cabart M, et al. J Hematol Oncol 2021;14(51):1-19.↵ 2. Robinson D, Van Allen EM, Wu Y, et al. Cell 2015;161(5):1215-1228.↵ 3. Scott RJ, Mehta A, Macedo GS, et al. Oncotarget 2021;12(16):1600-1614.↵
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